| Volume 27, Issue 2 | |
| Rare Allele 29 at Locus D2S1338 Observed During Routine Casework in Bulgarian Population | 73-82 |
| Plamen Iliev, Vera Djeliova, Ekaterina Angelova, Bogdan Mirchev, Atanas Hristov, Milka Mileva, Mihaela Georgieva, Kamen Peev, Nikolai Krastev, Dimo Krastev, Аleksandar Apostolov | |
| doi: 10.7546/ijba.2023.27.2.000900 | |
| [ +/- how to cite ][ +/- abstract ][ full text ] | |
| Plamen Iliev, Vera Djeliova, Ekaterina Angelova, Bogdan Mirchev, Atanas Hristov, Milka Mileva, Mihaela Georgieva, Kamen Peev, Nikolai Krastev, Dimo Krastev, Аleksandar Apostolov (2023) Rare Allele 29 at Locus D2S1338 Observed During Routine Casework in Bulgarian Population, Int J Bioautomation, 27 (2), 73-82, doi: 10.7546/ijba.2023.27.2.000900 | |
| Abstract: In this work, we report a rare allele 29 at locus D2S1338, established during routine forensic practice in a case of first-degree kinship (parenthood). This rare allele variant 29 at locus D2S1338, to the best of our knowledge, is reported for the first time for the Bulgarian population. So far it has not been registered in studies of allele frequencies in the same locus for 20 population groups in Europe and Asia. The presentation of similar genotyping findings relating to rare/unexpected population genetic variation is very important for the examination and documentation of such anomalies. The analysis has been performed for 16 STR loci: D2S1338, SE33, D16S539, D18S51, TH01, D12S391, D3S1358, FGA, vWA, D21S11, D1S1656, D2S441, D8S1179, D19S433, D22S1045, D10S1248 and 2 sex determination systems – Amelogenin and Y indel, set in NGM DetectTM PCR Amplification Kit (Applied Biosystems). The use of allelic witnesses in the diagnostic practice is mandatory in the standard fragment DNA analysis. The allelic witness contains well-known preset alleles for the examined locus. Establishing alleles that are outside the factory preset is of importance for broadening the scope of the witness and heightening the accuracy of the analysis. Rare allelic variants significantly increase the strength of discrimination when DNA profiles are compared. In this regard, it is important to report any new information about the emergence of rare allele variants detected in a particular population group.
Keywords: DNA analysis, STR, Rare allele, Locus D2S1338, Bulgarian population | |
| Detailed Investigation of Knee Biomechanics during Posture Maintenance while Applying Different Static Loadings on the Spine | 83-98 |
| Rositsa Raikova, Ivan Ivanov, Oleg Hristov, Nikol Markova, Lyudmil Trenev, Silvija Angelova | |
| doi: 10.7546/ijba.2023.27.2.000946 | |
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| Rositsa Raikova, Ivan Ivanov, Oleg Hristov, Nikol Markova, Lyudmil Trenev, Silvija Angelova (2023) Detailed Investigation of Knee Biomechanics during Posture Maintenance while Applying Different Static Loadings on the Spine, Int J Bioautomation, 27 (2), 83-98, doi: 10.7546/ijba.2023.27.2.000946 | |
| Abstract: The aim of this paper was to investigate in detail the biomechanics of the knee during different static loadings on the spine using electromyographic (EMG) signals from six main surface muscles acting in the knee joint; three components of the ground reaction force measured by a force plate; knee flexion joint angle measured by a flexible goniometer; and the distances between the bones (femur and tibia) forming the knee joint measured by an echograph. The measurements were taken without weight (reference straight position) and with a weight of 2, 5, 10, 15, 17, and 20 kg placed in a rucksack on the spine. The results showed that the forces in the horizontal and sagittal planes were negligible, and the reaction in the frontal plane increased and was linearly dependent on the carrying weight. The distance between bones decreased linearly with increasing weight for all participants from 3.94% to 53.92% from the referent position. The knee angle varied and in many cases decreased with increasing weight. The calculated correlation coefficients between mean EMG signals and loading weight showed that the adjustment of different subjects’ musculature to increasing load is individual. In general, knee joint balance is a dynamic individual process.
Keywords: Lower limb, Knee, EMG, Force plate, Echograph, Static loading | |
| An Analysis of the “Horizontal Y” Shaped Queuing Model to Assist in Health Care Institution | 99-106 |
| Manish Kumar Pandey, Dharmendra Kumar Gangeshwer | |
| doi: 10.7546/ijba.2023.27.2.000903 | |
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| Manish Kumar Pandey, Dharmendra Kumar Gangeshwer (2023) An Analysis of the “Horizontal Y” Shaped Queuing Model to Assist in Health Care Institution, Int J Bioautomation, 27 (2), 99-106, doi: 10.7546/ijba.2023.27.2.000903 | |
| Abstract: The “Horizontal Y” shaped queuing model in which there is bulk infinite arrival of patients, but available M services are limited. The discrete flow of patients in the system is reduced in continuous flow and a diffusion equation is used. In terms of means and variances of inter-arrival time distribution, this process of the number of patients and the number of servers is used, imposing reflecting boundaries. The inspiration for this analysis came from Aradhye and Kallurkar [2], and Armony [3], who explained that hospitals are complex systems whose problems can be resolved utilizing queuing theory. The present paper deals with a double-ended queue in which patients wait in a queue for services. The discrete distribution equations for queue size with various cases have been derived. Finally, the expected length of the queue, i.e., LC and the expected finite server, i.e., LS have been derived.
Keywords: Horizontal Y-shaped model, Health care institution, Model G∞/GM/1, Bulk arrival | |
| Assessment of the Factors Influencing the Survival of the Ventricular Shunt in Infantile Hydrocephalus | 107-116 |
| Lyudmila Todorova, Jivko Surchev, Alexander Marazov | |
| doi: 10.7546/ijba.2023.27.2.000926 | |
| [ +/- how to cite ][ +/- abstract ][ full text ] | |
| Lyudmila Todorova, Jivko Surchev, Alexander Marazov (2023) Assessment of the Factors Influencing the Survival of the Ventricular Shunt in Infantile Hydrocephalus, Int J Bioautomation, 27 (2), 107-116, doi: 10.7546/ijba.2023.27.2.000926 | |
| Abstract: The purpose of the present research is to perform a retrospective analysis of 242 ventricular shunts implanted in childhood due to infantile hydrocephalus, submitted to a long-term follow-up (27.84 ± 6.13 years) and investigate the factors influencing the survival of the shunt, applying modern mathematical approaches. The contingent consists of 242 patients who were shunted due to infantile hydrocephalus in childhood, 55% of whom were under 6 months old when the shunt was implanted. For the entire follow-up period, patients underwent 375 revisions (average 1.55 revisions per shunt), 38% are without shunt failure, with only one revision – 26%, with two – 14%. The remaining 22% have 3 or more revisions (4.58 shunt revisions) and they make 65% of all revisions. 68.5% of all revisions are due to mechanical complications; to functional (inadequate drainage) – 7.5%. 9.1% of the patients had inflammatory complications. We found that the age at shunting (under 3 months – the worst trend) and the interval to the first revision (over 6 months – a smaller number of revisions) are of the biggest importance for the number of the following revisions. If the patient survives one year after shunting without failure, the risk of such is under 50% during the whole shunt existence.
Keywords: Infantile hydrocephalus, Shunt complications, Shunt survival, Pediatric neurosurgery, InterCriteria analysis |
Sponsored by National Science Fund of Bulgaria, Grant No KP-06-NP4-25, 2023
© 2023, BAS, Institute of Biophysics and Biomedical Engineering