Biomacromolecules and Biomolecular Interactions | Main research topics

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Biofunctionalization of solid surfaces and optimization of their biocompatibility for application in medicine

  1. Andreeva T.D., Stoichev S., Taneva S.G., Krastev R. Hybrid graphene oxide/polysaccharide nanocomposites with controllable surface properties and biocompatibility. Carbohydrate Polymers, 2018, 181, 78-85
  2. Andreeva T.D., Hartmann H., Taneva S.G., Krastev R. Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions. J. Mater. Chem. B, 2016, 4, 7043-7170
    • The publication in Journal of Materials Chemistry B – Materials for Biology and Medicine selected for “HOT papers” 2016

Microcalorimetry of serum/plasma proteome ─ application as a screening technology for diagnostics and monitoring of diseases

  1. Danailova А., Todinova S., Dimitrova K., Petkova V., Guenova M., Mihaylov G., Gartcheva L., Krumova S., Taneva S. Effect of autologous stem-cells transplantation of patients with multiple myeloma on the calorimetric markers of the serum proteome. Correlation with the immunological markers. Thermochimica Acta, 2017, 655, 351–357
  2. Krumova S., Todinova S., Mavrov D., Marinov P., Atanassova V., Atanassov K., Taneva S.G. Intercriteria analysis of calorimetric data of blood serum proteome. Biochim. Biophys. Acta – General Subjects, 2017, 1861, 409-417
  3. Todinova S., Mavrov D., Krumova S., Marinov P., Atanassova V., Atanassov K., Taneva S.G. Blood Plasma Thermograms Dataset Analysis by Means of InterCriteria and Correlation Analyses for the Case of Colorectal Cancer. International Journal Bioautomation, 2016, 20, 115-124
  4. Krumova S., Todinova S., Danailova A., Petkova V., Dimitrova K., Gartcheva L., Taneva S.G. Calorimetric features of IgM gammopathies. Implication for patient’s diagnosis and monitoring. Thermochimica Acta, 2015, 615, 23–29
  5. Todinova S., Krumova S., Radoeva R., Gartcheva L., Taneva S.G. Calorimetric Markers of Bence Jones and Nonsecretory Multiple Myeloma Serum Proteome. Analytical Chemistry, 2014, 86, 12355–12361
  6. Arregi I., Olazabal-Herrero J.A., Alonso-Mariño M., Taneva S.G., Rodríguez J.A., Urbaneja M.A., Bañuelos S. Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport. PLoS ONE, 2015, 10(6), e0130610
  7. Krumova S., Rukova B., Todinova S., Gartcheva L., Milanova V., Toncheva D., Taneva S.G. Calorimetric monitoring of the serum proteome in schizophrenia patients. Thermochimica Acta, 2013, 572, 59-64
  8. Todinova S., Krumova S., Kurtev P., Dimitrov V., Djongov L., Dudunkov Z., Taneva S.G. Calorimetry-based profiling of blood plasma from colorectal cancer patients. Biochim. Biophys. Acta, 2012, 1820, 1879–1885.
  9. Todinova S., Krumova S., Gartcheva L. Robeerst C, Taneva S.G. Microcalorimetry of blood serum proteome: A modified iInteraction network in the multiple myeloma case. Anal. Chem., 2011, 83, 7992–7998.

Morphology and membrane elastic of platelets and erythrocytes in various pathologies

  • Todinova S., Komsa-Penkova R., Krumova S., Taneva S.G., Golemanov G., Georgieva G., Tonchev P., Tsankov B., Beshev L., Balashev K., Andreeva T. PlA2 Polymorphism in Glycoprotein IIb/IIIa Modulates the Morphology and Nanomechanics of Platelets. Clin Appl Thromb Hemost. 2017, 23(8), 951-960
  • Medical university – Pleven, Bulgaria
  • Sofia University “St. Kliment Ohridski”, Faculty of chemistry and pharmacy, Department of Physical chemistry, Sofia, Bulgaria
  • Institute for the Structure of Matter (ISM), Italian National Research Council (CNR), Rome, Italy

Thermal stability of proteins and protein complexes. Protein-ligand interactions and cofactors binding energetics (differential scanning calorimetry and isothermal titration calorimetry)

  1. Todinova S., Raynova Y., Idakieva K. Irreversible thermal denaturation of Helix aspersa maxima hemocyanin. Journal of Thermal Analysis and Calorimetry, 2018, 1-10
  2. Krumova S., Todinova S., Tileva M., Bouzhir-Sima L., Vos M.H., Liebl U., Taneva S.G. Thermal stability and binding energetics of Thymidylate Synthase ThyX. International Journal of Biological Macromolecules, 2016, 91, 560–567
  3. Szalontai B., Nagy G., Krumova S., Fodor E., Páli T., Taneva S.G., Garab G., Peters J., Dér A. Hofmeister ions control protein dynamics. Biochim. Biophys. Acta. 2013, 1830, 4564–4572

Structural organization of photosynthetic membranes of higher plants and cyanobacteria; thermodynamica beavior of pigment-protein complexes

  1. Petrova N., Todinova S., Laczko-Dobos H., Zakar T., Vajravel S., Taneva S., Gombos Z., Krumova S. Structural integrity of Synechocystis sp. PCC 6803 phycobilisomes evaluated by means of differential scanning calorimetry. Photosynth. Res. 2018,
  2. Stoichev S, Krumova S.B., Andreeva T, Busto J.V., Todinova S., Balashev K, Busheva M, Goṅi F.M., Taneva S.G. Low pH modulates the macroorganization and thermal stability of PSII supercomplexes in grana membranes. Biophys. J. 2015, 108, 844–853
  3. Krumova, S.B., Várkonyi, Zs., Lambrev, P.H., Kovács, L., Todinova, S.J., Busheva, M.C., Taneva, S.G., Garab, G. Heat- and light-induced detachment of the light-harvesting antenna complexes of photosystem I in isolated stroma thylakoid membranes. J. Photochem. Photobiol. B: Biology, 2014, 137, 4–12.
  4. Krumova S., Todinova S.J., Dobrikova A.G., Taneva S.G. Differential scanning calorimetry of photosynthetic membranes: Resolving contributions of the major photosynthetic complexes to the sequential thermal transitions. Trends Photochem. Photobiol. 2010, 12, 37–51.

Role of secondary metabolites and brassinosteroids for the structural organization and functionality of the photosynthetic apparatus

  1. Danova K., Motyka V., Todorova M., Trendafilova A., Krumova S., Dobrev P., Andreeva T., Oreshkova Ts., Taneva S., Evstatieva L.. Effect of cytokinin and auxin treatments on morphogenesis, terpenoid biosynthesis, photosystem structural organization, and endogenous isoprenoid cytokinin profile in Artemisia alba Turra in vitro. J. Plant Growth Regul. 2017,
  2. Krumova S., Zhiponova M., Dankov K., Velikova V., Balashev K., Andreeva T., Russinova E., Taneva S. Brassinosteroids regulate the thylakoid membrane architecture and the photosystem II function. J. Photochem. Photobiol. B: Biology, 2013, 126, 97–104
  3. Krumova S., Motyka V., Dobrev P., Todorova M., Trendafilova A., Evstatieva L., Danova K. Terpenoid profile of Artemisia alba is related to endogenous cytokinins in vitro. Bulg. J. Agricult. Sci. 2013, 19, 26-30
  • Institute of Organic Chemistry with Center for Phytochemistry, BAS, Sofia, Bulgaria
  • Sofia University “St. Kliment Ohridski”, Faculty of chemistry and pharmacy, Department of Physical chemistry, Sofia, Bulgaria

Macroorganization of protein and protein-lipid monolayers. Selforganization of the major light harvesting complex of photosystem II (LHCII)

  1. Andreeva T.D., Castano S., Krumova S., Lecomte S., Taneva S. Effect of Protonation on the Secondary Structure and Orientation of Plant Light-Harvesting Complex II Studied by PM-IRRAS. Langmuir, 2015, 31(42), 11583-11590
  2. Andreeva T.D., Krumova S.B., Minkov I.L., Busheva M., Lalchev Z., Taneva S.G. Protonation-induced changes in the macroorganization of LHCII monolayers. Coll. Surf. A: Physicochemical and Engineering Aspects, 2014, 460, 196–203
  • Sofia University “St. Kliment Ohridski”, Faculty of chemistry and pharmacy, Department of Physical Chemistry, Biological Faculty, Sofia, Bulgaria
  • Chimie et Biologie des Membranes et des Nanoobjets, CBMN-UMR University of Bordeaux 1 “Science and Technology“, Bordeaux, France

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