Biomacromolecules and Biomolecular Interactions | Main research topics

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Thermal stability of proteins and complex biological systems. Application of the thermodynamic approach in biomedicine – microcalorimetric screening of serum proteome and erythrocytes in various pathologies

Publications
Collaborators
  • National Specialized Hospital for Active Treatment of Hematological Diseases, Sofia, Bulgaria
  • Multiprofile hospital for active treatment in neurology and psychiatry “St. Nahum”
  • University Specialized Hospital for Active Treatment in Oncology, Sofia
  • “Prof. Dr Assen Zlatarov” University, Burgas

Nanomechanical and morphological properties of platelets and erythrocytes as biophysical markers for pathologies

Publications
  • Andreeva T., Komsa-Penkova R., Langari A., Krumova S., Golemanov G., Georgieva G.B., Taneva S.T., Giosheva I., Mihaylova N., Tchorbanov A., Todinova S., Morphometric and nanomechanical features of platelets from women with early pregnancy loss provide new evidence of the impact of inherited thrombophilia, International Journal of Molecular Sciences 2021, 22, 7778
  • Todinova S., Komsa-Penkova R., Krumova S., Taneva S.G., Golemanov G., Georgieva G., Tonchev P., Tsankov B., Beshev L., Balashev K., Andreeva T., PlA2 polymorphism in glycoprotein IIb/IIIa modulates the morphology and nanomechanics of platelets, Clinical and Applied Thrombosis/Hemostasis 2017, 23(8), 951-960, https://pubmed.ncbi.nlm.nih.gov/28081621/
Collaborators
  • Medical University – Pleven
  • “Acad. Jordan Malinowski” Institute of Optical Materials and Technologies
  • Sofia University “St. Kliment Ohridski”
  • Institute for the Structure of Matter (ISM), Italian National Research Council (CNR), Rome, Italy

Structural organization of pigment-protein complexes and photosynthetic membranes in higher plants and cyanobacteria, factors modulating their conformation, integrity and function


Publications
  1. Dlouhý O., Kurasová I., Karlický V., Javornik U., Šket P., Petrova N.Z.,  Krumova S.B., Plavec J., Ughy B., Špunda V., Garab G., Modulation of non-bilayer lipid phases and the structure and functions of thylakoid membranes: effects on the water-soluble enzyme violaxanthin de-epoxidase, Scientific Reports 2020, 10, 11959, https://www.nature.com/articles/s41598-020-68854-x
  2. Vajravel S., Laczkó-Dobos H., Petrova N., Herman Е., Kovács T., Zakar Т., Todinova S., Taneva S., Kovács L., Gombos Z., Tóth T., Krumova S., Phycobilisome integrity and functionality in lipid unsaturation and xanthophyll mutants in Synechocystis, Photosynthesis Research 2020, 145, 79–188, https://link.springer.com/article/10.1007/s11120-020-00776-1
  3. Petrova N., Paunov N., Stoichev S., Todinova S., Taneva S.G., Goltsev V., Krumova S., Thylakoid membrane reorganization, induced by growth light intensity, affects the plants susceptibility to drought stress, Photosynthetica 2020, 58(SI), 369-378, https://ps.ueb.cas.cz/artkey/phs-202002-0019_special-issue-in-honour-of-prof-reto-j-strasser-8211-thylakoid-membrane-reorganization-induced-by-growth.php
  4. Petrova N., Todinova S., Paunov M., Kovács L., Taneva S., Krumova S., Thylakoid membrane unstacking increases LHCII thermal stability and lipid phase fluidity, Journal of Bioenergetics and Biomembranes 2019, 50(6), 425-435, https://pubmed.ncbi.nlm.nih.gov/30607760/
  5. Petrova N., Stoichev S., Paunov M., Todinova S., Taneva S., Krumova S., Structural organization, thermal stability, and excitation energy utilization of pea thylakoid membranes adapted to low light conditions, Acta Physiologiae Plantarum 2019, 41, 188, https://link.springer.com/article/10.1007/s11738-019-2979-6
  6. Velikova V., Tsonev T., Tattini M., Arena C., Krumova S., Koleva D., Peeva V., Stojchev S., Todinova S., Izzo L.G., Brunetti C., Stefanova M., Taneva S., Loreto F., Physiological and structural adjustments of two ecotypes of Platanus orientalis L. from different habitats in response to drought and re-watering, Conservation Physiology 2018, 6(1): coy073 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301291/
  7. Petrova N., Todinova S., Laczko-Dobos H., Zakar T., Vajravel S., Taneva S., Gombos Z., Krumova S., Structural integrity of Synechocystis sp. PCC 6803 phycobilisomes evaluated by means of differential scanning calorimetry, Photosynthesis Research 2018, 137, 95–104, https://doi.org/10.1007/s11120-018-0481-4
Collaborators
  • Institute of Plant Biology, Biological Research Center, Szeged, Hungary
  • Sofia University “St. Kliment Ohridski”
  • Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences

Interaction of new carbon-based materials with biological molecules and membranes


Publications
  1. Taneva S.G., Krumova S., Bogár F., Kincses A., Stoichev S., Todinova S., Danailova A., Horváth J., Násztor Z., Kelemen L., Dér A., Insights into graphene oxide interaction with human serum albumin in isolated state and in blood plasma, International Journal of Biological Macromolecules 2021, 175, 19-29. https://www.sciencedirect.com/science/article/abs/pii/S0141813021001938?via%3Dihub
  2. Velikova V., Petrova N., Kovács L., Petrova A., Koleva D., Tsonev T., Taneva S., Petrov P, Krumova S., Single-Walled carbon nanotubes modify leaf micromorphology, chloroplast ultrastructure and photosynthetic activity of pea plants, International Journal of Molecular Sciences 2021, 22(9), 4878, https://doi.org/10.3390/ijms22094878
Collaborators
  • Institute of Biophysics, Biological Research Center, Szeged, Hungary
  • Institute of Plant Biology, Biological Research Center, Szeged, Hungary
  • Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences
  • Institute of Polymers, Bulgarian Academy of Sciences
  • Sofia University “St. Kliment Ohridski”

Biofunctionalization of hard surfaces and optimization of their biocompatibility for medical applications

Publications
  1. Andreeva T.D., Dér A., Kelemen L., Krastev R., Taneva S.G., Modulation of the internal structure and surface properties of natural and synthetic polymer matrices by graphene oxide doping, Polymers Advanced Technology 2020, 31, 7, 1562-1570, https://onlinelibrary.wiley.com/doi/abs/10.1002/pat.4885
  2. Rudt A., Andreeva T.D., Taneva S.G., Krastev R., Composite polyelectrolyte multilayers for biofunctionalization of medical devices, Current Directions in Biomedical Engineering 2020, 6, 3, 2020-3110https://www.degruyter.com/document/doi/10.1515/cdbme-2020-3110/html
  3. Andreeva T.D., Stoichev S., Taneva S.G., Krastev R. Hybrid graphene oxide/polysaccharide nanocomposites with controllable surface properties and biocompatibility, Carbohydrate Polymers, 2018, 181, 78-85, https://www.sciencedirect.com/science/article/abs/pii/S0144861717312092
  4. Andreeva T.D., Hartmann H., Taneva S.G., Krastev R. Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions, Journal of Materials Chemistry B, 2016, 4, 7043-7170, https://pubs.rsc.org/en/content/articlelanding/2016/tb/c6tb01638c#!divAbstract
    • The publication in Journal of Materials Chemistry B – Materials for Biology and Medicine selected for “HOT papers” 2016
Collaborators

 

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