Motor Control

Head of Department

Prof. Rositsa Raikova, DSc.

  • Email: rosi.raikovabiomed.bas.bg
  • Phone: (359 2) 9793654
  • Fax: (359 2) 8723787
  • Address: “Acad. G. Bonchev” Str., Block 105, Room 207A
    Sofia 1113, Bulgaria

Staff

Main research topics

Investigation of biomechanics and motor control of the human limbs, modeling and simulation of the motor activity at the muscle and motor units level. Investigation of the force developed by muscle motor units as a result of different stimulations. Experimental methods for estimation of muscle activity in norm and pathology – leader of the topic prof. R.Raikova

Application of mathematical modeling of bioelectrical processes in complex biophysical systems (nerves and skeletal muscles in norm and pathology) for improving the diagnostics and methods of treatment of neurological and neuromuscular disorders, including: 1) Modeling of intracellular potentials produced by skeletal muscle fibers as well as of extracellular potentials generated by muscles in order to adequately interpret the recorded electromyographic signals. 2) Modeling of electro-diffusion processes in myelinated axons including: a) Creation of computer-aided multi-cable research models of myelinated axon. b) Creation of adequate models of pump and transporter current by modeling stationary currents of cyclic chemical processes. c) Discovery of the mechanisms of phenomena observed experimentally in norm and pathology in the myelinated axon, by modeling them. – leader of the topic Assoc. Prof. A. Dimitrov

Relationship between intra- and extra-cellular action potentials of excitable cells: isolated muscle fibres, axons, neurons and estimation of their functional status (electrical, mechanical and enzyme activity. Experimental and modeling investigations on the specificity of the extracellular potential field  generated  from isolated muscle fibres, motor units and summated synchronously muscle potentials. Relationship between muscle structure and its electrical activity. Activity of separate muscle motor units in norm and pathology and its importance  for the whole muscle functioning. Fatigue of muscle fibers, motor units and whole muscle. Electromyographic estimation of the functional behaviour of the whole nerve-muscle system, sense-motor integration and motor control in norm and pathology – leader of the topic Corr. Mem. Prof. DSc. Andon Kossev

Computational neuroscience and numerical simulations of hereditary, chronic and acute demyelinating neuropathies and neuronopathies in cases of hypothermia (≤ 25°C), hyperthermia (≥ 40°C) and physiological temperature range (30°C –37°C).– leader of the topic: prof. Diana Stefanova

Experimental methods

Registering of potential of separate motor units using surface selective electrodes, electromyographic signals registration during isometric contractions and movements using surface and wire electrodes, transcranial magnetic stimulation.

Mathematical models

Simulation of double cable and myelin sheath multi-layered models without and with taking into account the temperature dependence in the range of 20°C –42°C of human motor nerve fibers.

Research projects

Current projects

  1. “Electromyographic investigations with aim to be used for rehabilitation with ortothic devices” , „ Program for Career Development of Young Scientists”, BAS , 2017-2019, coordinator S.Angelova
  2. “The model of skeletal muscle and simulation of muscle activity”. EBR-BAS-PAS, 2018-2021, coordinator Prof. R.Raikova

Past projects

  1. Development of a rat muscle model composed by realistic number of motor units and its experimental and modeling investigation by application of different patterns of MUs stimulation, Bilateral cooperation – Poland, 2012-2014, Coordinator: Prof. Rositsa Raikova
  2. Research of axo-glial interactions in myelinated axon Bulgarian National Science Fund, № ДМУ03/72, 2011–2014, Coordinator: Sen. Assist. Prof. Alexander Dimitrov
  3. Motor cortex excitability in health and disease, Institute partnership program of Alexander von Humboldt Foundation between the Institute of biophysics of Bulgarian Academy of Sciences and the Neurology Clinic of Medical University of Hannover (MHH), 2003-2006. coordinator Corr.Mem. Prof A. Kossev
  4. Ghrelin-dependent modulation of contraction and membrane ionic currents in resistant arteries, Bulgarian National Science Fund, Grant  No 1407/2004, 2004-2009 Coordinator: Prof. D. Duridanova and Prof. A. Kossev
  5. Corticospinal motor excitability changes preceding reaction time movement, Bulgarian National Science Fund, Grant  No 1407/2004, B-1505/05, 2005-2009.
  6. Temperature effect on the excitability properties in simulated demyelinating neuropathies and neuronopathies. № 03.2012, 2012-2013 between IBPhBME and Medical University – Varna. Head: Prof. Diana Stephanova
  7. Effect of the myelin sheath liquid layers on the membrane properties of simulated demyelinating neuropathies. № 29/4/10, 2010-2012 between IBPhBME and Medical University – Varna. Head: Prof. Diana Stephanova
  8. The molecular basis of nerve excitability in man: a patch clamp of ion channels and pumps in human myelinated axons,  grant G900630N, 1989–1991 from the MRC, Institute of Neurology, London, IBPhBME Head: Assistant Professor Diana Stephanova 

International collaboration

  • Department of Neurobiology, University School of Physical Education, Poznan, Poland

Awards

  • 2015 – Prof. R.Raikova  – Award from the Union of Scientists in Bulgaria for high scientific achievements
  • 2006 – assoc. prof. Maria Esenturk – award “Ivan Geshov” for most young scientist in BAS
  • 2003 – Assoc. Prof. Diana Stephanova – Diploma and award from the Ministry of Education and Science, National Scientific Research Council for achievements in the development of the research project “Electrogenesis in human myelinated and demyelinated nerve fibers: mathematical modeling” in the 8th competition session 1998–2001..

Selected publications

  1. Alexandrov A.S., Vassileva P., Momchilova A., Tsonchev Z., Kirilova Y., Ivanova R., Sapundzhiev P., Petkova D.,  Tzoneva R.,  Daskalov M.,  Orozova M.,  Kenarov P.  (2016)  A new approach using nanomembranebased therapeutic plasmapheresis for treatment of patients with multiple sclerosis and neuromyelitis optica. Comp Ren. Bulg. Sci,  69, 373-385.
  2. Angelova S., Raikova R., Chakarov V., Aladjov H. (2013) Estimation of the upper arm motor deficit in stroke patients using EMG signals – A preliminary study. Series on Biomechanics, 28 (1-2),  20-27.
  3. Angelova S., Ribagin S., Raikova R., Veneva I. (2017) Power frequency spectrum analysis of surface EMG signals of upper limb muscles during elbow flexion – a comparison between healthy subjects and stroke survivors. Journal of Electromyography and Kinesiology (accepted).
  4. Angelova P., Momchilova A., Petkova D., Staneva G., Pankov R.,Kamenov Z. (2012) Testosteron replacement therapy improves erythrocyte membrane lipid composition in hypogonadal men. The aging male, 15,173-179.
  5. Arabadzhiev T.I., Dimitrov G.V., Chakarov V.E., Dimitrov A.G., Dimitrova N.A. (2008) Effects of changes in intracellular action potential on potentials recorded by single fiber, macro, and belly-tendon electrodes. Muscle and Nerve, 37(6), 700-712 .
  6. Arabadzhiev T..I, Dimitrov G.V., Dimitrov A.G., Chakarov V.E., Dimitrova N.A. (2008) Factors affecting the turns analysis of the interference EMG signal. Biomedical Signal Processing and Control, 3(2), 145-153.
  7. Arabadzhiev T.I., Dimitrov G.V., Chakarov V.E., Dimitrov A.G., Dimitrova N.A. (2008) Changes in intracellular action potential profile affect parameters used in turns/amplitude analysis. Muscle and Nerve, 37(6), 713-720.
  8. Arabadzhiev T.I., Dimitrov V.G., Dimitrova N.A., Dimitrov G.V. (2010) Interpretation of integral or RMS EMG and estimate of “neuromuscular efficiency” in fatiguing contraction can be misleading. Journal of Electromyography and Kinesiology, 20, 2, 223-232.
  9. Arabadzhiev T.I., Dimitrov V.G., Dimitrova N.A., Dimitrov G.V. (2010) Influence of motor unit synchronization on amplitude characteristics of surface and intramuscularly recorded EMG signals. European Journal of Applied Physiology, 108, 2, 227-237.
  10. Arabadzhiev T.I., Dimitrov V.G., Dimitrov G.V. (2014) The increase in surface EMG could be a misleading measure of neural adaptation during the early gains in strength. European Journal of Applied Physiology, 114, 8, 1645-1655.
  11. Celichowski J., Raikova R., Drzymala-Celichowska H., Ciechanowicz I., Krutki P., Rusev R.  (2008) Model-generated decomposition of motor unit unfused  tetani evoked at random stimulation pattern. Journal of Biomechanics, 3448-3454.
  12. Celichowski J.,  Raikova R., Aladjov H.,  Krutki P. (2014)  Dynamic changes of twitch-like responses to successive stimuli studied by decomposition of motor unit tetanic contractions in rat medial gastrocnemius. Journal of Neurophysiology,  112, 3116-3124.
  13. Celichowska-Drzymala H., Raikova R., Krutki P. (2016) Prolonged activity evokes potentiation and the “sag” phenomenon in slow motor units of rat soleus. Acta Neurobiol. Exp., 76, 152-157.
  14. Christov I., Raikova R., Angelova S. Separation of electrocardiographic from electromyographic signals using dynamic filtration. Medical Engineering and Physics (accepted)
  15. Christova L., Georgieva B, Koryak Yu. A., Kozlovskaja I. B., Kossev A. (2008) Muscle functional state assessment by estimation of muscle conduction velocity. Human Physiology, 34(6), 742–747.
  16. Christova L., Kaloypsis S., Diafas V., Stanbolieva K., Kossev A. (2011) Assessment of training process by estimation of muscle fibre conduction velocity. Comt. r. Acad. bulg. sci., 64(6), 845-850.
  17. Damyanova R., Lupanova T., Petkova D., Markovska T., Ivanova L., Staneva G., Wolf Cl., Pankov R., Momchilova A. (2010) Oxidative stress-induced alteractions in fibroblast plasma membrane lipids. Compt. Ren. Bulg. Acad. Sci., 63, 1321-1326.
  18. Damyanova R., Markovska T., Mitev V., Staneva G., Petkova D. (2010) Uptake of fatty acids by fibroblasts cultured in three-dimentional matrix. Compt. Ren. Bulg. Acad. Sci., 63, 999-1002.
  19. Daskalova M., Krustev S.M., Stephanova D.I. (2013) Temperature effects on simulated human nodal action potentials and their defining current kinetics. Scripta Scientifica Medica, 45(3), 42-47.
  20. Dimitrov A.G. (2017) An approach to expand description of the pump and co-transporter steady-state current. Journal of Theoretical Biology, 412, 94-99.
  21. Dimitrov A.G., Dimitrova N.A. (2014) Internodal mechanism of pathological afterdischarges in myelinated axons. Muscle and Nerve, 49 (1), 47-55.
  22. Dimitrov A.G., Dimitrova N.A. (2013) Axonal afterdischarges: problems and mechanisms. In: Axons: Cell Biology, Molecular Dynamics and Roles in Neural Repair and Rehabilitation., 178-240  Nova Science Publishers Inc.,  ISBN:9781629480510
  23. Dimitrov A.G., Dimitrova N.A. (2012) A possible link of oxaliplatin-induced neuropathy with potassium channel deficit. Muscle and Nerve, 45(3),  403-411.
  24. Dimitrov A.G. (2009) A possible mechanism of repetitive firing of myelinated axon. Pflugers Arch – Eur J Physiol, 458(3), 547-561.
  25. Dimitrov V. G., Arabadzhiev T. I., Dimitrova N. A., Dimitrov G. V. (2009) Eccentric contraction-induced muscle fiber adaptation. Bioautomation, 13, 4, 119-126.
  26. Dimitrov V.G., Arabadzhiev T.I., Dimitrova N.A., Dimitrov G.V. (2012) The spectral changes in EMG during a second bout eccentric contraction could be due to adaptation in muscle fibres themselves: a simulation study. European Journal of Applied Physiology, 112, 4, 1399-1409.
  27. Drzymała-Celichowska H., Raikova R., Krutki P. (2015) Decomposition of motor unit tetanic contractions of rat soleus muscle: Differences between males and females. Journal of Biomechanics,  48(12), 3097-3102.
  28. Gallasch E., Christova M., Krenn M., Kossev A.R., Rafolt D. (2009) Changes in motor cortex excitability following training of a novel goal-directed motor task.  Eur. J. Appl. Physiol., 105(1), 47-54.
  29. Georgieva R.,  Momchilova A., Petkova D., Koumanov K., Staneva G. (2013) Effect of N-propyl gallate on lipid peroxidation in heterogenous model membranes. Biotechnology and Biotechnology Equipment, 27, 4145-4149.
  30. Hazarosova R., Momchilova A., Koumanov K., Petkova D., Staneva G. (2015) Role of aminophospholipids in the formation of lipid rafts in model membranes. J Fluoresc.,  25, 1037-1043.
  31. Krustev S.M., Daskalova M., Stephanova D.I. (2013) Temperature effects on simulated human internodal action potentials and their defining current kinetics. Scripta Scientifica Medica, 45(4), 36-40.
  32. Krustev S.M., Stephanova D.I. (2012) Effect of the myelin sheath aqueous layers on the action potentials in simulated hereditary and chronic demyelinating neuropathies. Scripta Scientifica Medica, 44(2), 53-57.
  33. Krustev S.M., Stephanova D.I. (2012) Abnormalities in the recovery cycles in simulated demyelinating neuropathies and neuronopathies. Scripta Scientifica Medica, 44(2), 59-63.
  34. Krustev S.M., Negrev N., Stephanova D.I. (2012) The strength-duration properties in simulated demyelinating neuropathies depend on the myelin sheath aqueous layers. Scripta Scientifica Medica, 44(1), 117-123.
  35. Krustev S., Daskalova M., Stephanova D. (2010) Myelin sheath aqueous layers do not modulate membrane fibre properties of simulated cases of paranodal internodal systematic demyelinations. CR Acad Bulg Sci, 63(12), 1845-1852.
  36. Krutki P., Pogrzebna M., Drzymala H., Raikova R., Celichowski J. (2008) Force generated by fast motor units of the rat medial gastrocnemius muscle during stimulation with pulses at variable intervals. Journal of Physiology and Pharmacology, 59, 85-100.
  37. Krutki P., Celichowski J., Raikova R (2012) Motor unit contractions evoked by stimulation with variable interpulse intervals. Biocybernetics and Biomedical Engineering, 32 (3),  29-42.
  38. Krutki P., Mrówczyński W., Raikova R., Celichowski J. (2014) Concomitant changes in afterhyperpolarization and twitch following repetitive stimulation of fast motoneurones and motor units. Experimental Brain Research,  232 (2), 443-452.
  39. Mancheva K., Stephanova D.I., Wolf W., Kossev A. (2017) Long-lasting intracortical inhibition during unilateral muscle activity. Badnjevic (ed.) in CMBEBIN, IFMBE proceedings, 62, 333-338.
  40. Mrówczyński  W., Celichowski J., Raikova R., Krutki P. (2015) Physiological consequences of doublet discharges on motoneuronal firing and motor unit force. Frontiers in Cellular Neuroscience, 9, Art.No 81, 1-6.
  41. Nikolova M., Pondev N., Christova L., Wolf W., Kossev A. (2010) Effect of subthreshold transcranial magnetic stimulation on reaction time. Comt. r. Acad. bulg. sci., 63(2), 241-248.
  42. Petkova D.,  Staneva G.,  Markovska T., Iliev I.,  Ivanova I., Chakarov S.,  Pankov R., Momchilova A. (2012)  Fructooligosaccharide intake alters the phospholipid and fatty acid composition of liver plasma membranes. Biotech.Biotech.Eq., 26,  1310-2818.
  43. Petkova D., Momchilova A., Slotte J.P. (2010) Tumor necrosis factor-alfa stimulates sphingomyelin turnover in human skin fibroblasts by two different pathways. Biotech. Biotehn.Eq, 24, 1631-1637.
  44. Raikova R., Pogrzebna M., Drzymała H., Celichowski J., Aladjov H. (2008) Variability of successive contractions subtracted from unfused tetanus of fast and slow motor units. Journal of Electromyography and Kinesiology, 18, 741-751.
  45. Raikova  R. (2009) Investigation of the influence of the elbow joint reaction on the predicted muscle forces using different optimization functions. Journal of Musculoskeletal Research, 12, 1-13.
  46. Raikova (2010) Some considerations about the prediction of muscle forces for multi-joints biomechanical models. Series on Biomechanics, 25 (3-4), 23-32.
  47. Raikova R., Rusev R., Drzymała-Celichowska H., Krutki P., Aladjov H., Celichowski J. (2010)  Experimentally verified mathematical approach for prediction of force developed by motor units at variable frequency stimulation patterns. Journal of Biomechanics, 43, 1546-1552.
  48. Raikova R.,Tahtakov K., Chakarov V. (2011) Technical device for prevention of spinal column disorders. Pilot EMG study for estimation of back muscle activity. International Journal  Bioautomation,  5(2), 115-130.
  49. Raikova R.T. (2012) Indeterminate problems in biomechanics – models of muscles and their control (summary paper). Series on Biomechanics, 26 (1-2), 5-16.
  50. Raikova R., Aladjov H., Celichowski J., Krutki P. (2013) An approach for simulation of the muscle force modeling it by summation of motor unit contraction forces.  Computational and Mathematical Methods in Medicine,  Art. No. 625427.
  51. Raikova R., Angelova S., Chakarov C., Krastev D. (2014) An approach for experimental investigation of muscle activities of the upper limbs (right versus left arm) of healthy subjects and post-stroke patients – a preliminary study. International Journal  Bioautomation, 18(2) 101-110.
  52. Raikova R., Aladjov H., Krutki P.,  Celichowski J. (2015) Estimation of the error between experimental tetanic force curves of MUs of rat medial gastrocnemius muscle and their models by summation of equal successive contractions. Computer Methods in Biomechanics and Biomedical Engineering, 19(7), 763-770.
  53. Raikova R., Celichowski J., Krutki P. (2016) A general mathematical algorithm for predicting the course of unfused tetanic contractions of motor units in rat muscle. Plos One. September 13, 2016, http://dx.doi.org/10.1371/journal.pone.0162385
  54. Raikova R., Angelova S.,  Ribagin S. (2016) Changes in EMG activities of upper arm muscles and in shoulder joint angles in post-stroke patients.  International Journal  Bioautomation,  20(3), 389-406.
  55. Rusev R., Raikova , Celichowski J. (2009) Prediction of tetanic force of muscle motor units evoked by irregular stimulation patterns. International Journal Bioautomation,  13 (4), 101-110.
  56. Staneva G.,  Lupanova T.,  Chachaty C., Petkova D., Koumanov K., Pankov R.,  Momchilova A. (2011) Structural organization of plasma membrane lipids isolated from cells cultured as a monolayer and in tissue-like conditions, Journal of Colloids and Interface Science , 359, 202-209.
  57. Stephanova D.I., Kossev A. (2018) Theoretical predication of temperature effects on adaptive processes in simulated amyotrophic lateral sclerosis at 20oC-42oC. Journal of Integrative Neuroscience (in press)
  58. Stephanova D.I., Dimitrov B. (2013) Computational neuroscience: simulated demyelinating neuropathies and neuronopathies, Taylor and Francis Group,  CRC Press Inc., Boca Raton, London, New York, pp.1-148.
  59. Stephanova D.I., Kossev A. (2017) Temperature effects on accommodative processes in simulated amyotrophic lateral sclerosis in the physiological range. Journal of Integrative Neuroscience, 16, 319-333.
  60. Stephanova D.I., Kossev A. (2016) Theoretical predication of temperature effect on accommodative processes in simulated amyotrophic lateral sclerosis during hypothermia and hyperthermia. Journal of Integrative Neuroscience, 15(4), 553-569.
  61. Stephanova D.I., Kossev A. (2016) Theoretical predication of temperature effect on conducting processes in simulated amyotrophic lateral sclerosis at 20–42oC. Journal of Integrative Neuroscience, 15(2), 261-276.
  62. Stephanova D.I., Daskalova M., Mladenov M. (2016) Internodal action potentials and their current kinetics in simulated chronic inflammatory demyelinating polyneuropathy at 20oC−42oC. CR Acad Bulg Sci, 69(1), 99-104.
  63. Stephanova D.I., Daskalova M., Kossev A. (2015) Effects of temperatures on adaptive processes in simulated chronic inflammatory demyelinating polyneuropathy at 20oC−42oC. Biomath Communications, 2(2), 7-29.
  64. Stephanova D.I., Daskalova M. (2015) Electrotonic potentials in simulated chronic inflammatory demyelinating polyneuropathy at 20oC−42oC. Journal of Integrative Neuroscience, 14(2), 235-252.
  65. Stephanova D.I., Daskalova M. (2015) Conducting processes in simulated chronic inflammatory demyelinating polyneuropathy at 20oC−42oC. Journal of Integrative Neuroscience, 14(1), 19–30.
  66. Stephanova D.I., Daskalova M. (2014) Theoretical predications of the effects of temperature on simulated adaptive processes in human motor nerve axons at 20oC−42oC. Journal of Integrative Neuroscience, 13(3), 529–543.
  67. Stephanova D.I., Daskalova M. (2014) Effects of temperature on simulated electrotonic potentials and their current kinetics of human motor axons at 20−42oC. Journal of Integrative Neuroscience, 13(3), 447–464.
  68. Stephanova D.I., Daskalova M., Krustev S.M. (2013) Modified multi-layered model of temperature dependent motor nerve axons. Scripta Scientifica Medica, 45(3), 36-41.
  69. Stephanova D.I., Krustev S.M., Negrev N. (2012) Mechanisms defining the electrotonic potential abnormalities in simulated amyotrophic lateral sclerosis. Journal of Integrative Neuroscience, 11(2), 155-167.
  70. Stephanova D.I., Krustev S.M., Negrev N. (2012) Mechanisms defining the action potential abnormalities in simulated amyotrophic lateral sclerosis. Journal of Integrative Neuroscience, 11(2), 137-154.
  71. Stephanova D.I., Krustev S.M., Negrev N., Daskalova M. (2011) The myelin sheath aqueous layers improve the membrane properties of simulated chronic demyelinating neuropathies. Journal of Integrative Neuroscience, 10(1), 105-120.
  72. Stephanova D.I., Krustev S.M., Daskalova M. (2011) The aqueous layers within the myelin sheath modulate the membrane properties of simulated hereditary demyelinating neuropathies. Journal of Integrative Neuroscience, 10(1),89-103.
  73. Stephanova D.I. (2010) Comparison of membrane property abnormalities in simulated demyelinating neuropathies and neuronopathies. CR Acad Bulg. Sci., 63(3), 435-442.
  74. Stephanova D.I., Daskalova M. (2009) Homogeneity or heterogeneity membrane polarization in simulated cases of demyelinating neuropathies without or with conduction block. CR Acad Bulg Sci, 62(8), 1015-1022.
  75. Stefanova N., Staneva G., Petkova D., Lupanova T., Pankov R., Momchilova A. (2009) Cell culturing in a three-dimensional matrix affects the localization and properties of plasma membrane cholesterol. Cell Biol Int. , 33, 1079-1086.
  76. Stephanova D., Daskalova M. (2008) Differences between the channels, currents and mechanisms of conduction slowing/block and accommodative processes in simulated cases of focal demyelinating neuropathies. European Biophysics Journal, 37(6), 829-842.
  77. Stephanova D., Daskalova M. (2008) Membrane property abnormalities in simulated cases of mild systematic and severe focal demyelinating neuropathies. European Biophysics Journal, 37(2), 183-195.
  78. Lupanova T., Petkova D., Markovska T., Staneva G.,. Chakarov St., Skrobanska R., Pankov R., Momchilova A. (2012) Effect of cholesterol modulation on the antioxidant potential of quarcetin in rat liver plasma membranes. Compt.Ren. Bulg. Acad. Sci., 65,639-644.
  79. Lupanova T.,Markovska T., Petkova D., Staneva G., L.Ivanova L., Wolf Cl., Pankova R., A. Momchilova A. (2010) Lipid peroxidation in control and ras-transformed fibroblasts after incorporation of polyunsaturated fatty acids. Compt.Ren. Bulg. Acad. Sci., 63, 1163-1168.
  80. Lupanova T., Ivanova L., Staneva G., Markovska T., Petkova D., Pankov  R., Momchilova A. (2010)  Plasma membrane phospholipase A2 substrate specificity is altered by cell culturing in three-dimentional environment. Compt.Ren. Bulg. Acad. Sci., 63, 543-546.
  81. Lupanova T., Stefanova N., Petkova D., Staneva G., Jordanova A., Koumanov K., Pankov R., Momchilova A. (2010). Alteration in the content and physiological role of sphingomyelin in plasma membranes of cells cultured in three-dimentional matrix. Mol.Cell Biol, 340, 215-222.
  82. Mancheva K., Karaivanova E., Atanasov G., Stojanovski S., Nedeva I. (2009) Analysis of the influence of the host body size on morphometrical characteristics of Ancylodiscoides siluri and Ancylodiscoides vistulensis. Biotechnology & Biotechnological Equipment, 23(2), 735-741.
  83. Mancheva K., Christova L., Kossev A. (2013) Effects of muscle activation mode on reaction time. Comptes rendus de l’Académie bulgare des Sciences 66 (11), 1633-1638.
  84. Mancheva K., Schrader C., Christova L., Dengler R., Kossev A.R. (2014) The effect of muscle vibration on short latency intracortical inhibition in humans. European Journal of Applied Physiology 114 (10), 2073-2080.
  85. Mancheva K., Rollnik J.D., Wolf W., Dengler R., Kossev A. (2017) Vibration-induced kinesthetic illusions and corticospinal excitability changes. Journal of Motor Behavior 49(3), 299-305.
  86. Mileva K.N., Bowtell J.L., Kossev A.R. (2009) Effects of low frequency whole body vibration on motor evoked potentials in healthy men. Exp. Physiol., 94(1), 103-116.
  87. Momchilova A., Petkova D., Staneva G.,  Markovska T.,  Pankov R.,  Skrobanska R.,  Nikolova-Karakashian  M.,  Koumanov K. (2014)  Resveratrol alters the lipid composition, metabolism and peroxide level in senescent rat hepatocytes. Chem-Biol Interact,  207,  74-80.
  88. Momchilova A.,  Petkova D.,  Staneva G.,  Markovska T.,  Pankov St. ,  Pankov R. (2014) Influence of xylooligosaccharide intake on liver plasma membrane lipids in rats. Comp Ren. Bulg. Sci, 67, 355-360.
  89. Momchilova A. , Petkova D., Staneva G., Pankov St., Skrobanska R., Evangelatov A. ,  Pankov R. (2013) Applicability of l-buthionines-s, r-sulfoximine for development of a model of aged cells. Comp Ren. Bulg. Sci, 66, 1695-1700.
  90. Momchilova A., Petkova D., Staneva G.,  Markovska T., Pankov St.,  Pankov R. (2014) Influence of xylooligosaccharide intake on liver plasma membrane lipids in rats. Comp Ren. Bulg. Sci, 67, 355-360.
  91. Petkova D., Markovska T.,  Staneva G.,  Scrobanska R.,  Momchilova A. (2013). Effect of inulin intake on the content and susceptibility to oxidative damage of cholesterol in rat liver plasma membranes. C. R. Acad. Bulg. Sci., 66 , 401-406.
  92. Petkova D. (2011) PhD education in Bulgaria. Turkish J.Biochem, 36, 45-48.
  93. Petkova D., Pankov R, Markovska T., Staneva G., Stefanova N., Ivanova L., Momchilova A. (2009)  Sphingomyelin content affects the activity of membrane-bound alkaline phosphatase. Compt.Ren. Bulg. Acad. Sci., 62, 469-473.
  94. Schrader C., Peschel T., Kossev, A.R. (2008) Verarbeitung von propriozeptiver information beim idiopathischem Parkinson-syndrom und der einfluss von levodopa. Klin. Neurophysiol., 39:194-200.
  95. Schrader C., Siggelkow S., Rollnik J.D., Kossev, A.R. (2008) Impaired proprioception in amyotrophic lateral sclerosis – A study using muscle vibration and transcranial magnetic stimulation. Klin. Neurophysiol., 39(4), 262-266.
  96. Schrader C., Peschel T., Däuper J., Rollnik J.D., Dengler R., Kossev A. (2008) Changes in processing of proprioceptiv information in Parkinson’s disease and multiple system atrophy. Clin. Neurophysiol., 119, 1139-1146.
  97. Staneva G.,  Petkova D.,  Hazarosova R.,  Georgieva R.,  Pankov R.,  Skrobanska R.,  Momchilova A. (2014) Intake of Xylooligosaccharides alters the structural organization of liver plasma membrane bilayer. Food Biophysics, 9,  138-144.
  98. Staneva G., Petkova D.,  Markovska T.,  Scrobanska R.,  Momchilova  A. (2014) Beta‑glucans alter cholesterol level and susceptibility to oxidation in rat hepatocytes. Comp Ren. Bulg. Sci, 67, 1383-1387.
  99. Staude G., Rabe M., Wolf W., Kossev A., Bauch  G. (2010) A novel setup for investigations of reflexive and reactive motor responses in biceps. IFMBE Proceedings, 25(4), 461-463.
  100. Vukova T.I., Dimitrov V., Radicheva N. (2010) Three methods for estimation of changes in frequency characteristics of potentials elicited by long-lasting (fatiguing) activity of isolated muscle fibres. 29, 3, General Physiology and Biophysics, 243-254.
  101. Христова Л., Георгиева Б., Коряк Ю.А., Козловская И.Б., Косев А. (2008) Влияние конфигурации электродов на скорость проведения возбуждения при регистрации интерференционной электромиограммы. Физиология человека, 34(6), 100-105.

Monography

  • Косев A., Александров A., Даскалов M. (2012) Транскраниална магнитна стимулация в норма и патология., Академично издателство „Проф. Марин Дринов”, София, под печат  (ISBN: 978-954-322-163)

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