Motor Control

Head of Department

Prof. Rositsa Raikova, DSc.

  • Email: rosi.raikovabiomed.bas.bg
  • Phone: (359 2) 9793654
  • Fax: (359 2) 8723787
  • Address: “Acad. G. Bonchev” Str., Block 105, Room 207A
    Sofia 1113, Bulgaria

Staff

Main research topics

Investigation of biomechanics and motor control of the human limbs, modeling and simulation of the motor activity at the muscle and motor units level. Investigation of the force developed by muscle motor units as a result of different stimulations. Experimental methods for estimation of muscle activity in norm and pathology – leader of the topic prof. R.Raikova

Application of mathematical modeling of bioelectrical processes in complex biophysical systems (nerves and skeletal muscles in norm and pathology) for improving the diagnostics and methods of treatment of neurological and neuromuscular disorders, including: 1) Modeling of intracellular potentials produced by skeletal muscle fibers as well as of extracellular potentials generated by muscles in order to adequately interpret the recorded electromyographic signals. 2) Modeling of electro-diffusion processes in myelinated axons including: a) Creation of computer-aided multi-cable research models of myelinated axon. b) Creation of adequate models of pump and transporter current by modeling stationary currents of cyclic chemical processes. c) Discovery of the mechanisms of phenomena observed experimentally in norm and pathology in the myelinated axon, by modeling them. – leader of the topic Assoc. Prof. A. Dimitrov

Relationship between intra- and extra-cellular action potentials of excitable cells: isolated muscle fibres, axons, neurons and estimation of their functional status (electrical, mechanical and enzyme activity. Experimental and modeling investigations on the specificity of the extracellular potential field  generated  from isolated muscle fibres, motor units and summated synchronously muscle potentials. Relationship between muscle structure and its electrical activity. Activity of separate muscle motor units in norm and pathology and its importance  for the whole muscle functioning. Fatigue of muscle fibers, motor units and whole muscle. Electromyographic estimation of the functional behaviour of the whole nerve-muscle system, sense-motor integration and motor control in norm and pathology – leader of the topic Corr. Mem. Prof. DSc. Andon Kossev

Computational neuroscience and numerical simulations of hereditary, chronic and acute demyelinating neuropathies and neuronopathies in cases of hypothermia (≤ 25°C), hyperthermia (≥ 40°C) and physiological temperature range (30°C –37°C).– leader of the topic: prof. Diana Stefanova

Experimental methods

Registering of potential of separate motor units using surface selective electrodes, electromyographic signals registration during isometric contractions and movements using surface and wire electrodes, transcranial magnetic stimulation.

Mathematical models

Simulation of double cable and myelin sheath multi-layered models without and with taking into account the temperature dependence in the range of 20°C –42°C of human motor nerve fibers.

Research projects

Current projects

  1. “Electromyographic investigations with aim to be used for rehabilitation with ortothic devices” , „ Program for Career Development of Young Scientists”, BAS , 2017-2019, coordinator S.Angelova
  2. “The model of skeletal muscle and simulation of muscle activity”. EBR-BAS-PAS, 2018-2021, coordinator Prof. R.Raikova

Past projects

International collaboration

  • Department of Neurobiology, University School of Physical Education, Poznan, Poland

Awards

  • 2015 – Prof. R.Raikova  – Award from the Union of Scientists in Bulgaria for high scientific achievements
  • 2006 – assoc. prof. Maria Esenturk – award “Ivan Geshov” for most young scientist in BAS
  • 2003 – Assoc. Prof. Diana Stephanova – Diploma and award from the Ministry of Education and Science, National Scientific Research Council for achievements in the development of the research project “Electrogenesis in human myelinated and demyelinated nerve fibers: mathematical modeling” in the 8th competition session 1998–2001..

Selected publications

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