Sen. Assist. Prof. Iglika Lessigiarska, PhD | Publications

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Publications in periodical journals, proceedings, and EC reports

  1. Netzeva, T., Natcheva, R., Doychinova, I., Lesigiarska, I., Mihailova, D. (1998). Theoretical investigation of the chemical structure and QSAR-analysis of a series of 9-substituted artemisinin derivatives. Archives of the Balkan Medical Union, 33 (4), 189-198.
  2. Milchev, A., Michailova, E., Lesigiarska, I. (2000). Spatial distribution of active sites on a glassy carbon surface. Electrochemistry Communications, 2, 407-411.
  3. Лесигярска, И., Пъжева, И., Пандова, Б., Янев, С. (2000). Quantitative structure-activity relationship (QSAR) и 3D QSAR анализ на серия алкилксантати като инхибитори и инактиватори на Цитохром P-450 2B1. Научни известия на научно-техническия съюз по машиностроене, 3 (54), 150 – 155.
  4. Lesigiarska, I., Pajeva, I. (2001). QSAR and 3D QSAR in drug design: cytochrome P-450 inhibitors and antiinflammatory agents. Proceedings of International Symposium and Yong Scientists’ School “Bioprocess Systems”, 1-3 October 2001, Sofia, Bulgaria, pp. A17-A20.
  5. Sasselov, D., Atanasov, K., Lessigiarska, I., Radeva, V. (2001). A generalized net model of a mixture of gas and collisioness massive particles inside a strong potential. Proceedings of Workshop on Intuitionistic Fuzzy Sets and Generalized Nets, 6-7 November 2001, Varshava, Poland.
  6. Lesigiarska, I., Pajeva, I., Yanev, S. (2002). Quantitative structure-activity relationship (QSAR) and three-dimensional QSAR analysis of a series of xanthates as inhibitors and inactivators of cytochrome P450 2B1. Xenobiotica, 32 (12), 1063 – 1077.
  7. Lessigiarska, I., Worth, A. (2003). The use of computer models as alternatives to animal experiments in chemical risk assessment. Alternatives to Laboratory Animals, 31, 67-73.
  8. Gennari, A., Van den Berghe, C., Casati, S., Castell, J., Clemedson, C., Coecke, S., Colombo, A., Curren, R., Dal Negro, G., Goldberg, A., Gosmore, C., Hartung, T., Langezaal, I., Lessigiarska, I., Maas, W., Mangelsdorf, I., Parchment, R., Prieto, P., Sintes, J.R., Ryan, M., Schmuck, G., Stitzel, K., Stokes, W., Vericat, J.A., Gribaldo, L. (2004). Strategies to replace in vivo acute systemic toxicity testing. The report and recommendations of ECVAM Workshop 50. Alternatives to Laboratory Animals, 32 (4), 437-59.
  9. Lessigiarska, I., Cronin, M.T.D., Worth, A.P., Dearden, J.C., Netzeva, T.I. (2004). QSARs for toxicity to the bacterium Sinorhizobium meliloti. SAR and QSAR in Environmental Research, 15, 169-190.
  10. Lessigiarska, I., Worth, A.P., Sokull-Klüttgen, Jeram, S., Dearden, J.C., Netzeva, T.I., Cronin, M.T.D. (2004). QSAR investigation of a large data set for fish, algae and Daphnia toxicity. SAR and QSAR in Environmental Research, 15, 413-431.
  11. Lessigiarska, I., Nankov, A., Bocheva, A. Pajeva, I., Bijev, A. (2005). 3D-QSAR and preliminary evaluation of anti-inflammatory activity of series of N-pyrrolylcarboxylic acids. Il Farmaco, 60, 209-218.
  12. Lessigiarska, I., Pajeva, I., Cronin, M.T.D., Worth, A.P. (2005). 3D QSAR investigation of the blood-brain barrier penetration of chemical compounds. SAR and QSAR in Environmental Research, 16, 79-91.
  13. Lessigiarska, I., Worth, A.P., Netzeva, T.I. (2005). Comparative review of QSARs for acute toxicity. EUR report No. 21559 EN. EC Joint Research Centre Ispra, Italy.
  14. Netzeva, T.I., Aptula, A.O., Benfenati, E., Cronin, M.T.D., Gini, G., Lessigiarska, I., Maran, U., Vracko, M., Schüürmann, G. (2005). Description of the electronic structure of organic chemicals using semiempirical and ab initio methods for development of toxicological QSARs. Journal of Chemical Information and Modeling, 45, 106-114.
  15. Lessigiarska, I., Worth, A.P., Netzeva, T.I., Dearden, J.C., Cronin, M.T.D. (2006). Quantitative structure–activity–activity and quantitative structure–activity investigations of human and rodent toxicity. Chemosphere, 65, 1878–1887.
  16. Tsakovska, I., Lessigiarska, I., Netzeva, T., Worth, A. (2006). Review of (Q)SARs for Mammalian Toxicity. EUR report No. 22486 EN. EC Joint Research Centre Ispra, Italy.
  17. Tzakovska, I., Lessigiarska, I., Netzeva, T., Pajeva, I., Worth., A.P. (2006). Review of Quantitative Structure – Activity Relationships for Acute Mammalian Toxicity. Bioautomation, 5, 90-105
  18. Tsakovska, I., Lessigiarska, I., Netzeva, T., Worth, A.P. (2008). A mini review of mammalian toxicity (Q)SAR models. QSAR & Combinatorial Science, 27(1), 41-48
  19. Lessigiarska, I., Pajeva, I., Prodanova, P., Georgieva, M., Bijev, A. (2012). Structure-activity relationships of pyrrole hydrazones as new anti-tuberculosis agents. Medicinal Chemistry, 8(3), 462-473
  20. Georgiev, G., Ilieva, N., Kozhuharov, V., Lessigiarska, I., Litov, L., Pavlov, B., Petkov, P. (2013). Multigap RPC for PET: development and optimisation of the detector design. Journal of Instrumentation, 8 (01), P01011
  21. Stoyanova, T., Lessigiarska, I., Mikov, M., Pajeva, I., Yanev, S. (2017). Xanthates as useful probes for testing the active sites of Cytochromes P450 4A11 and 2E1. Frontiers in Pharmacology, 8, ISSN:1663-9812, Article 67. ISI IF:4.4

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