Head of Department
Prof. Sashka Boychova Krumova, PhD
- E-mail: sashka.b.krumova@gmail.com
- Phone: (359) 2 979 2608
- Fax: (359) 2 872 3787
- Address: “Acad. G. Bonchev” Str., Block 21, Room 218,
Sofia 1113, Bulgaria
Staff
- Prof. Stefka Germanova Taneva, DSc., sgtaneva@gmail.com
- Assoc. Prof. Svetla Zhelyazkova Todinova, PhD, todinova@abv.bg
- Assoc. Prof. Tonya Dimitrova Andreeva, PhD, t_andreeva@abv.bg
- Assist. Prof. Roumiana Todorova Todorova, PhD, todorova@bio21.bas.bg
- Sen. Assist. Prof. Svetozar Dimitrov Stoichev, PhD, svetlio85@abv.bg
- Sen. Assist. Prof. Avgustina Krasimirova Danailova, PhD, avgustina_danailova@abv.bg
- Se. Assict. Prof. Nia Zlatkova Petrova, PhD, biologist, petrova_nia@yahoo.com
- Assist. Prof. Ariana Anuar Langari, PhD student, arianalangari@abv.bg
- Assist. Prof. Maria Plamenova Ganova, maria.ganova@abv.bg
- Ina Nikolai Giosheva, biologist, ina_gi@abv.bg
- Ognian Konstantinov Apostolov, biochemist, oapostolov@googlemail.com
- Velichka Jordanova Strijkova-Kenderova, physicist, vily@iomt.bas.bg
Main research topics
Application of thermodynamics in medicine – microcalorimetry of serum proteome (screening technology for diagnostics and monitoring of wide range of diseases) and red blood cells (mechanisms of cells ageing).
Dynamics of biological macromolecules and structure/function relationship. Thermal stability of proteins and complex biological systems. Macroorganization of pigment-protein complexes, factors modulating their conformation, integrity and function (lipids, biogenic organic compounds, steroids, ion strength and others).
Interactions of new carbon-based nanomaterials with biological molecules and membranes.
Nanomechanical and morphological properties of platelets and red blood cells as pathological biomarkers.
Biofunctionalization of solid surfaces and optimization of their biocompatibility for application in medicine.
Research projects
Current projects
- New biophysical markers for diagnosis of abnormalities in the coagulation system during pregnancy in high risk,
Institute of Biophysics and Biomedical Engineering, KP-06-Н21/4, 18.12.2018
Coordinator: Assoc. Prof. Svetla Todinova - Encapsulation of peptide-based drugs in natural, synthetic and hybrid nano- and microcapsules, 2017-2019,
Institute of Biophysics, University of Natural Resources and Life Sciences – BOKU, Vienna, DAAD Austria 01/7, 2017
Coordinator: Prof. Stefka Taneva - Thin biocompatible hybrid coatings for protein and cell/surface interactions
Institute of Biophysics, Biological Research Center, Hungarian Academy of Sciences, Hungary, Bilateral cooperation – 2019-2021
Coordinator: Prof. Stefka Taneva - Structure-functional characterization of cyanobacterial mutants during state transitions
Biological research Center, Hungarian Academy of Sciences, 2019-2021, EBR
Coordinator: Assoc. Prof. Radka Vladkova - Construction of hybrid biodegradable microcapsules with controlled properties for use in biomedicine, КP-06-M21/4, 12.12.2018
National Science Fund
Coordinator: Sen. Assit. Svetozar Stoichev - New approach for cancer treatment by epitope-specific tumours inhibition, 2017 – 2020,
National Science Fund, Institute of organic chemistry with center of phytochemistry, H 19116, 10.12.2017
Coordinator: Assoc. Prof. Krasimira Idakieva - New chemically modified hemocyanins with potential application as anticancer agents, 2017 – 2019,
National Science Fund, European Program for scientific research and Technology COST – COST Action CA 16231; 2017-2019
Coordiunator: Assoc. Prof. Maya Guncheva
Past projects (last 5 years) Selected publications (last 5 years)
2014 – 2016 joint project with Medical University – Pleven, Bulgaria
Project leader: Assoc. Prof. Regina Komsa_Penkova
PhD student Avgustina Danailova
Аssist. Prof. Svetozar Stoichev
Italy, Institute for the Structure of Matter, Italian National Research Council, Rome, Italy, Bilateral cooperation – 2016-2018
Coordinator: Prof. Stefka Taneva
2014-2016 National Science Fund, № ДНТС 01/9
Project leader: Prof. Stefka G. Taneva
Collaborator: NMI Natural and Medical Sciences Institute at the University of Tübingen, Tübingen, Germany
Institute of Plant Biology, Biological Research Center, Hungarian Academy of Sciences Hungary
Bilateral cooperation – 2016-2018
Coordinator: Assoc. Prof. Sashka Krumova
Institute of Biophysics, Biological Research Center, Hungarian Academy of Sciences, Hungary, Bilateral cooperation – 2016-2018
Coordinator: Prof. Stefka Taneva
Coordinator:Assist. Prof. Nia Petrova
Coordinator:PhD student Avgustina DanailovaInternational collaboration
Lecture courses
Journal of Bioenergetics and Biomembranes, 2019, 50(6):425-435
Thylakoid membrane unstacking increases LHCII thermal stability and lipid phase fluidity
doi: 10.1007/s10863-018-9783-7
European Biophysics Journal 2019, 48(5):465-473
Spectrokinetic characterization of photoactive yellow protein films for integrated optical applications
doi: 10.1007/s00249-019-01353-8.
Conservation Physiology 2018, 6(1): coy073; doi:10.1093/conphys/coy073
Physiological and structural adjustments of two ecotypes of Platanus orientalis L. from different habitats in response to drought and re-watering
doi: 10.1093/conphys/coy073
Thermochimica Acta 2018, 666, 208-211
Calorimetric manifestation of IgA monoclonal immunoglobulins in multiple myeloma será
https://doi.org/10.1016/j.tca.2018.07.005
Journal of Molecular Recognition 2018, Jun 6:e2732. doi: 10.1002/jmr.2732
Insight into the Morphological Pattern Observed Along the Erythrocytes’ Aging: Coupling Quantitative AFM Data to microcalorimetry and Raman spectroscopy
doi: 10.1002/jmr.2732
Photosynthesis Research 2018, 137, 95-104
Structural integrity of Synechocystis sp. PCC 6803 phycobilisomes evaluated by means of differential scanning calorimetry
doi: 10.1007/s11120-018-0481-4
European Biophysics Journal 2018, 47, 549-559
Calorimetric markers for monitoring of multiple myeloma and Waldenström’s macroglobulinemia patients,
https://doi.org/10.1007/s00249-018-1277-3
Photosynth. Res. 2018, 137(1):95-104
Structural integrity of Synechocystis sp. PCC 6803 phycobilisomes evaluated by means of differential scanning calorimetry
https://rd.springer.com/article/10.1007/s11120-018-0481-4
Carbohydrate Polymers 181, 2018, 78-85
Hybrid graphene oxide/polysaccharide nanocomposites with controllable surface properties and biocompatibility,
https://doi.org/10.1016/j.carbpol.2017.10.053
Colloids and Surfaces B: Biointerfaces 161, 2018, 192-199
Effects of Ca2+, Glu and GABA on hBest1 and composite hBest1/POPC surface films.
doi: 10.1016/j.colsurfb.2017.10.051
Journal of Plant Growth Regulation, 2018, 37: 403
Effect of Cytokinin and Auxin Treatments on Morphogenesis, Terpenoid Biosynthesis, Photosystem Structural Organization, and Endogenous Isoprenoid Cytokinin Profile in Artemisia alba Turra In Vitro,
https://doi.org/10.1007/s00344-017-9738-y
Biochim. Biophys. Acta – General Subjects 1861, 2017, 409-417
Intercriteria analysis of calorimetric data of blood serum proteome,
doi: 10.1016/j.bbagen.2016.10.012
Clinical and Applied Thrombosis/Hemostasis 2017, 23(8):951-960
PlA2 polymorphism in glycoprotein IIb/IIIa modulates the morphology and nanomechanics of platelets,
https://doi.org/10.1177/1076029616687847
Colloids and Surfaces B: Biointerfaces, 149, 2017, 226-232
Effects of Ca2+ ions on bestrophin-1 surface films.
doi: 10.1016/j.colsurfb.2016.10.023
Journal of Materials Chemistry. B 4, 2016, 7043-7170
Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions,
doi: 10.1039/C6TB01638C
International Journal of Biological Macromolecules 91, 2016, 560– 567
Thermal stability and binding energetics of Thymidylate Synthase ThyX,
doi: 10.1016/j.ijbiomac.2016.05.083
Cancer Research Froniters 2, 2016, 416-426,
Unusual thermal transition in the serum calorimetric profile of Bence Jones multiple myeloma: a case report,
doi: 10.17980/2016.416
Thermochimica Acta 625, 2016, 95-101
Calorimetric signatures of human cancer cells and their nuclei,
https://doi.org/10.1016/j.tca.2015.11.002
Langmuir 31, 2015, 11583-11590
Effect of Protonation on the Secondary Structure and Orientation of Plant Light-Harvesting Complex II Studied by PM-IRRAS,
doi: 10.1021/acs.langmuir.5b02653
PLoS ONE 10(6) (2015) e0130610
Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport,
doi: 10.1371/journal.pone.0130610
Biophysical Journal 108, 2015, 844–853
Low pH Modulates the Macroorganization and Thermal Stability of PSII Supercomplexes in Grana Membranes
doi: 10.1016/j.bpj.2014.12.042
Thermochimica Acta 615, 2015, 23–29
Calorimetric features of IgM gammopathies. Implication for patient’s diagnosis and monitoring,
doi: 10.1016/j.bpj.2014.12.042
Current Stem Cell Research & Therapy, 9, 2014, 1, Bentham Science Publishers
Ewing’s sarcoma cancer stem cell targeted therapy
DOI: 10.2174/1574888X08666131203123125
Anticancer Research 34, 2014, 10
Functional domains and IPD targeted therapy for Ewing’s sarcoma
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 460, 2014, 196–203
Protonation-induced changes in the macroorganization of LHCII monolayers,
https://doi.org/10.1016/j.colsurfa.2013.12.044
Journal of Photochemistry and Photobiology B: Biology, 137, 2014, 4–12
Heat- and light-induced detachment of the light-harvesting antenna complexes of photosystem I in isolated stroma thylakoid membranes,
https://doi.org/10.1016/j.jphotobiol.2014.04.029