Biomacromolecules and Biomolecular Interactions

Head of Department

Prof. Stefka Taneva, DSc.

  • E-mail:
  • Phone: (359 2) 9792625
  • Fax: (359 2) 8723787
  • Address: “Acad. G. Bonchev” Str., Block 21, Room 314
    Sofia 1113, Bulgaria


Main research topics

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Dynamics of biological macromolecules and structure/function relationship. Thermal stability of proteins and complex biological systems. Macroorganization of pigment-protein complexes, factors modulating their conformation, integrity and function (lipids, biogenic organic compounds, steroids, ion strength and others). Application of thermodynamics in medicine – microcalorimetry of serum proteome (screening technology for diagnostics and monitoring of wide range of diseases).

Research projects

Current projects

  1. Application of atomic force microscopy for the investigation of platelets derived from patients with deep venous thrombosis, carriers of trombocytic polymorphisms
    2014 – 2016 joint project with Medical University – Pleven, Bulgaria
    Project leader: Assoc. Prof. Regina Komsa_Penkova
  2. Optimized polyelectrolyte multilayer coatings for biofunctionalization of coronary stents
    2014-2016 National Science Fund, №  ДНТС 01/9
    Project leader: Prof. Stefka G. Taneva
    Collaborator: NMI Natural and Medical Sciences Institute at the University of Tübingen, Tübingen, Germany
  3. Thermodynamic behaviour of tumour cells. Effect of antitumour agents
    Budgetary subsidy, 2014-2017
    Coordinator: Prof. Stefka Taneva
  4. Morphology and topology of the main Light-harvesting complex of photosystem II (LHCII) studied by Brewster angle microscopy and Atomic force microscopy
    Budgetary subsidy, 2014-2015
    Coordinator: Sen. Assist Prof. Dr Tonia Andreeva
  5. Light-energy conversion and molecular dynamics in retinal proteins. Bioelectronic application
    Bilateral cooperation – Hungary. Deadline, 2014-2015
    Coordinator: Prof. Stefka Taneva
  6. Investigation of the stability of DNA metabolic enzymes and thier interactions with ligands by means of spectroscopic, biochemical and thermodynamic methods
    Bulgarian Science Fund, ДРИЛА-01-11, 2013-2015
    Coordinator: Prof. Mira Busheva
  7. Thermodynamic investigation of blood serum, novel approach for monitoring of haematological diseases (multiple myeloma)
    Budgetary subsidy, 2011-2014
    Coordinator: Prof. Stefka Taneva
  8. Unstructured proteins and Ewing Sarcoma
    Budgetary subsidy, 2011-2014
    Coordinator: Sen. Assist. Prof. Dr. Rumiana Todorova

Past projects

International collaboration

  • NMI Natural and Medical Sciences Institute at the University of Tübingen, Tübingen, Germany
  • Laboratoire d’optique et biosciences, Ecole Polytechnique INSERM U696 – CNRS, Palaiseau, France
  • Chimie et Biologie des Membranes et des Nanoobjets, CBMN-UMR, University of Bordeaux 1 “Science and Technology“, Bordeaux, France
  • Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary
  • Unidad de Biofísica (CSIC/UPV) y Departamento de Bioquímica y Biología Molecular, Universidad del País Vasco, Bilbao, Spain
  • Max Planck Institute of Colloids and Interfaces, Department of Interfaces, Research Campus Potsdam-Golm, Potsdam, Germany

Lecture courses

  • New developments and trends in protein science – Institute of Biophysics and Biomedical Engineering, BAS
  • Biomaterial science – Seminar series and laboratory exercises for the students course, Faculty of Chemistry, Sofia University

Selected publications

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