Biomacromolecules and Biomolecular Interactions

Head of Department

Prof. Stefka Germanova Taneva, DSc.

  • E-mail:
  • Phone: (359) 2 9792625
  • Fax: (359) 2 8723787
  • Address: “Acad. G. Bonchev” Str., Block 21, Room 314, Sofia 1113, Bulgaria


Main research topics

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Dynamics of biological macromolecules and structure/function relationship. Thermal stability of proteins and complex biological systems. Macroorganization of pigment-protein complexes, factors modulating their conformation, integrity and function (lipids, biogenic organic compounds, steroids, ion strength and others). Application of thermodynamics in medicine – microcalorimetry of serum proteome (screening technology for diagnostics and monitoring of wide range of diseases).

Research projects

Current projects

  1. Encapsulation of peptide-based drugs in natural, synthetic and hybrid nano- and microcapsules, 2017-2019, Institute of Biophysics, University of Natural Resources and Life Sciences – BOKU, Vienna, DAAD Austria 01/7, 2017
  2. Coordinator: Assoc. Prof. Tonya Andreeva
  3. Human erythrocyte’s ageing in healthy and pathological subjects, studied by differential scanning calorimetry, atomic force microscopy and biochemical patterns
    Italy, Institute for the Structure of Matter, Italian National Research Council, Rome, Italy, Bilateral cooperation – 2016-2018
    Coordinator: Prof. Stefka Taneva
  4. Surface biofunctunalization of solid surfaces for bioelectronic applications,
    Institute of Biophysics, Biological Research Center, Hungarian Academy of Sciences, Hungary, Bilateral cooperation – 2016-2018
    Coordinator: Prof. Stefka Taneva
  5. 4. Factors modulating the structural organization, stability and oxidative stress resistance of cyanobacterial thylakoid membranes
    Institute of Plant Biology, Biological Research Center, Hungarian Academy of Sciences, Hungary, Bilateral cooperation – 2016-2018
    Coordinator: Assoc. Prof. Sashka Krumova
  6. Investigation of the stability of DNA metabolic enzymes and thier interactions with ligands by means of spectroscopic, biochemical and thermodynamic methods
    Bulgarian Science Fund, ДРИЛА-01-11, 2013-2015
    Coordinator: Assoc. Prof. Sashka Krumova
  7. Role of photosystem II ordering in thylakoid membranes of higher plants for their resistance towards drought stress, ДФНП-17-138, 2017
    Coordinator:Res. Assoc. Nia Petrova
  8. Calorimetric Plasma Proteome Assay for Early Diagnosis of Malignant Diseases. In vivo experimental models of colorectal carcinoma, ДФНП 17-133/2017
    Coordinator:PhD student Avgustina Danailova

Past projects

International collaboration

  • NMI Natural and Medical Sciences Institute at the University of Tübingen, Tübingen, Germany
  • Laboratoire d’optique et biosciences, Ecole Polytechnique INSERM U696 – CNRS, Palaiseau, France
  • Chimie et Biologie des Membranes et des Nanoobjets, CBMN-UMR, University of Bordeaux 1 “Science and Technology“, Bordeaux, France
  • Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary
  • Unidad de Biofísica (CSIC/UPV) y Departamento de Bioquímica y Biología Molecular, Universidad del País Vasco, Bilbao, Spain
  • Max Planck Institute of Colloids and Interfaces, Department of Interfaces, Research Campus Potsdam-Golm, Potsdam, Germany

Lecture courses

    • New developments and trends in protein science – Institute of Biophysics and Biomedical Engineering, BAS

Model membranes – Seminar series and laboratory exercises for the master students course, Faculty of Biology, Sofia University

Selected publications

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