Биомакромолекули и биомолекулни взаимодействия | Основни научни направления

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Биофункционализиране на твърди повърхности и оптимизиране на биосъвместимостта им за приложение в медицината

Избрани
  1. Andreeva T.D., Stoichev S., Taneva S.G., Krastev R. Hybrid graphene oxide/polysaccharide nanocomposites with controllable surface properties and biocompatibility. Carbohydrate Polymers, 2018, 181, 78-85
  2. Andreeva T.D., Hartmann H., Taneva S.G., Krastev R. Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions. J. Mater. Chem. B, 2016, 4, 7043-7170
    • The publication in Journal of Materials Chemistry B – Materials for Biology and Medicine selected for “HOT papers” 2016
Колаборатори

Микрокалориметрия на серумен/плазмен протеом ─ приложение като скрининг технология за диагностика и мониторинг на заболявания

Избрани
  1. Danailova А., Todinova S., Dimitrova K., Petkova V., Guenova M., Mihaylov G., Gartcheva L., Krumova S., Taneva S. Effect of autologous stem-cells transplantation of patients with multiple myeloma on the calorimetric markers of the serum proteome. Correlation with the immunological markers. Thermochimica Acta, 2017, 655, 351–357
  2. Krumova S., Todinova S., Mavrov D., Marinov P., Atanassova V., Atanassov K., Taneva S.G. Intercriteria analysis of calorimetric data of blood serum proteome. Biochim. Biophys. Acta – General Subjects, 2017, 1861, 409-417
  3. Todinova S., Mavrov D., Krumova S., Marinov P., Atanassova V., Atanassov K., Taneva S.G. Blood Plasma Thermograms Dataset Analysis by Means of InterCriteria and Correlation Analyses for the Case of Colorectal Cancer. International Journal Bioautomation, 2016, 20, 115-124
  4. Krumova S., Todinova S., Danailova A., Petkova V., Dimitrova K., Gartcheva L., Taneva S.G. Calorimetric features of IgM gammopathies. Implication for patient’s diagnosis and monitoring. Thermochimica Acta, 2015, 615, 23–29
  5. Todinova S., Krumova S., Radoeva R., Gartcheva L., Taneva S.G. Calorimetric Markers of Bence Jones and Nonsecretory Multiple Myeloma Serum Proteome. Analytical Chemistry, 2014, 86, 12355–12361
  6. Arregi I., Olazabal-Herrero J.A., Alonso-Mariño M., Taneva S.G., Rodríguez J.A., Urbaneja M.A., Bañuelos S. Leukemia-Associated Mutations in Nucleophosmin Alter Recognition by CRM1: Molecular Basis of Aberrant Transport. PLoS ONE, 2015, 10(6), e0130610
  7. Krumova S., Rukova B., Todinova S., Gartcheva L., Milanova V., Toncheva D., Taneva S.G. Calorimetric monitoring of the serum proteome in schizophrenia patients. Thermochimica Acta, 2013, 572, 59-64
  8. Todinova S., Krumova S., Kurtev P., Dimitrov V., Djongov L., Dudunkov Z., Taneva S.G. Calorimetry-based profiling of blood plasma from colorectal cancer patients. Biochim. Biophys. Acta, 2012, 1820, 1879–1885.
  9. Todinova S., Krumova S., Gartcheva L. Robeerst C, Taneva S.G. Microcalorimetry of blood serum proteome: A modified iInteraction network in the multiple myeloma case. Anal. Chem., 2011, 83, 7992–7998.
Колаборатори

Морфология и мембранна еластичност на тромбоцити и еритроцити при различни патологии

http://biomed.bas.bg/bg/wp-content/uploads/2018/01/bbi-18-t3-f1.png

Избрани
  • Todinova S., Komsa-Penkova R., Krumova S., Taneva S.G., Golemanov G., Georgieva G., Tonchev P., Tsankov B., Beshev L., Balashev K., Andreeva T. PlA2 Polymorphism in Glycoprotein IIb/IIIa Modulates the Morphology and Nanomechanics of Platelets. Clin Appl Thromb Hemost. 2017, 23(8), 951-960
Колаборатори
  • Medical university – Pleven, Bulgaria
  • Sofia University “St. Kliment Ohridski”, Faculty of chemistry and pharmacy, Department of Physical chemistry, Sofia, Bulgaria
  • Institute for the Structure of Matter (ISM), Italian National Research Council (CNR), Rome, Italy

Температурна стабилност на протеини и протеинови комплекси. Протеин-лиганд взаимодействия и енергетика на свързване на кофактори (диференциална сканираща калориметрия и изотермична титрационна калориметрия)

Избрани
  1. Todinova S., Raynova Y., Idakieva K. Irreversible thermal denaturation of Helix aspersa maxima hemocyanin. Journal of Thermal Analysis and Calorimetry, 2018, 1-10
  2. Krumova S., Todinova S., Tileva M., Bouzhir-Sima L., Vos M.H., Liebl U., Taneva S.G. Thermal stability and binding energetics of Thymidylate Synthase ThyX. International Journal of Biological Macromolecules, 2016, 91, 560–567
  3. Szalontai B., Nagy G., Krumova S., Fodor E., Páli T., Taneva S.G., Garab G., Peters J., Dér A. Hofmeister ions control protein dynamics. Biochim. Biophys. Acta. 2013, 1830, 4564–4572
Колаборатори

Структурна организация на фотосинтетични мембрани при висши растения и цианобактерии; термодинамично поведение на пигмент-белтъчни комплекси

Избрани
  1. Petrova N., Todinova S., Laczko-Dobos H., Zakar T., Vajravel S., Taneva S., Gombos Z., Krumova S. Structural integrity of Synechocystis sp. PCC 6803 phycobilisomes evaluated by means of differential scanning calorimetry. Photosynth. Res. 2018, https://doi.org/10.1007/s11120-018-0481-4
  2. Stoichev S, Krumova S.B., Andreeva T, Busto J.V., Todinova S., Balashev K, Busheva M, Goṅi F.M., Taneva S.G. Low pH modulates the macroorganization and thermal stability of PSII supercomplexes in grana membranes. Biophys. J. 2015, 108, 844–853
  3. Krumova, S.B., Várkonyi, Zs., Lambrev, P.H., Kovács, L., Todinova, S.J., Busheva, M.C., Taneva, S.G., Garab, G. Heat- and light-induced detachment of the light-harvesting antenna complexes of photosystem I in isolated stroma thylakoid membranes. J. Photochem. Photobiol. B: Biology, 2014, 137, 4–12.
  4. Krumova S., Todinova S.J., Dobrikova A.G., Taneva S.G. Differential scanning calorimetry of photosynthetic membranes: Resolving contributions of the major photosynthetic complexes to the sequential thermal transitions. Trends Photochem. Photobiol. 2010, 12, 37–51.
Колаборатори

Роля на вторични метаболити и брасиностероиди за структурната организация и функционалността на фотосинтетичния апарат

Избрани
  1. Danova K., Motyka V., Todorova M., Trendafilova A., Krumova S., Dobrev P., Andreeva T., Oreshkova Ts., Taneva S., Evstatieva L.. Effect of cytokinin and auxin treatments on morphogenesis, terpenoid biosynthesis, photosystem structural organization, and endogenous isoprenoid cytokinin profile in Artemisia alba Turra in vitro. J. Plant Growth Regul. 2017, https://doi.org/10.1007/s00344-017-9738-y
  2. Krumova S., Zhiponova M., Dankov K., Velikova V., Balashev K., Andreeva T., Russinova E., Taneva S. Brassinosteroids regulate the thylakoid membrane architecture and the photosystem II function. J. Photochem. Photobiol. B: Biology, 2013, 126, 97–104
  3. Krumova S., Motyka V., Dobrev P., Todorova M., Trendafilova A., Evstatieva L., Danova K. Terpenoid profile of Artemisia alba is related to endogenous cytokinins in vitro. Bulg. J. Agricult. Sci. 2013, 19, 26-30
Колаборатори
  • Institute of Organic Chemistry with Center for Phytochemistry, BAS, Sofia, Bulgaria
  • Sofia University “St. Kliment Ohridski”, Faculty of chemistry and pharmacy, Department of Physical chemistry, Sofia, Bulgaria

Макроорганизация на протеин и протеин-липидни монослоеве. Самоорганизация на светосъбиращ комплекс II

Избрани
  1. Andreeva T.D., Castano S., Krumova S., Lecomte S., Taneva S. Effect of Protonation on the Secondary Structure and Orientation of Plant Light-Harvesting Complex II Studied by PM-IRRAS. Langmuir, 2015, 31(42), 11583-11590
  2. Andreeva T.D., Krumova S.B., Minkov I.L., Busheva M., Lalchev Z., Taneva S.G. Protonation-induced changes in the macroorganization of LHCII monolayers. Coll. Surf. A: Physicochemical and Engineering Aspects, 2014, 460, 196–203
Колаборатори
  • Sofia University “St. Kliment Ohridski”, Faculty of chemistry and pharmacy, Department of Physical Chemistry, Biological Faculty, Sofia, Bulgaria
  • Chimie et Biologie des Membranes et des Nanoobjets, CBMN-UMR University of Bordeaux 1 “Science and Technology“, Bordeaux, France